Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC Amadacycline 389139-89-3 200mg
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Amadacycline (CAS 389139-89-3) is a tetracycline-class antibiotic targeting the bacterial ribosomal 30S subunit It is designed to inhibit bacterial protein synthesis thereby preventing microbial proliferation Amadacycline exerts its biological activity primarily through interference with bacterial translation by inhibiting the 30S ribosomal subunit The exact IC50 value for Amadacycline has not been established Based on these pharmacological properties Amadacycline holds research potential in investigating antibiotic resistance mechanisms bacterial ribosome-targeting strategies and as a candidate in studies evaluating therapeutic agents for complicated skin and skin structure infections
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TARGETMOL CHEMICALS INC TPCK 200MG
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Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis Purity 96.77%
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TARGETMOL CHEMICALS INC L-Sodium lactate 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. (L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids. Purity 99.17%
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Medchemexpress LLC 8PPD-Q | 99.9% | 326.43 | 5 MG
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8PPD-Q, a para-phenylenediamine quinone, is a rubber antioxidant. It has superior antioxidant and anti-ozone activities but is toxic to the aquatic species, especially salmonids. 8PPD-Q can be used for environmental pollution research.
- Functions as a para-phenylenediamine quinone compound.
- Acts as a rubber antioxidant.
- Exhibits superior antioxidant activities.
- Provides superior anti-ozone activities.
- Applicable for environmental pollution research.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370629 SCH900776 200MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000371584 MPEG-AMINE MW 750 50MG
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Medchemexpress LLC Firmonertinib (mesylate) | 2130958-55-1 | 100.0% | 664.70 | 500 MG
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Firmonertinib mesylate (Alflutinib; Furmonertinib) is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation, with potential for research into cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations and the T790M acquired resistant mutation
- Potential for research of cancer diseases, particularly advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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eMolecules 7-BROMOQUINOLINE 5G
5000169985 7-BROMOQUINOLINE 5G
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Apexbio Technology LLC Quinidine 56-54-2 50mg
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Quinidine (CAS 56-54-2) is a small-molecule inhibitor targeting sodium (Na ) and potassium (K ) ion channels It is designed to inhibit these ion channel currents thereby modulating cardiac electrophysiological processes Quinidine exerts its biological activity primarily through inhibition of Na and K currents In in vitro studies quinidine demonstrates inhibitory activity with an IC50 of approximately 41 M on the transient outward potassium current (Ik) at a membrane potential of 0 mV Based on these pharmacological properties quinidine holds research potential in the fields of cardiac electrophysiology ion channel pharmacology drug metabolism and drug-drug interaction mechanisms
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Medchemexpress LLC Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
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Guanidinoethyl sulfonate (Standard) | 543-18-0 | 99.9% | 167.19 | 10 MG
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Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg
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AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes
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Research Products International Corp Leupeptin Hemisulfate 1 G
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Reversible inhibitor of cysteine and serine proteases resembling trypsin, Inhibits cathepsin B, kallikrein, papain, plasmin, thrombin and trypsin.
Working concentration: 1-10uM
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Medchemexpress LLC DC-BPi-03 | 2758411-46-8 | C14H14N4O2S | 10 MM/1 ML
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DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC50 of 698.3 nM and a Kd of 2.81 μM. It is for research use only and not sold to patients.
- Potent BPTF-BRD inhibitor
- IC50 of 698.3 nM
- Kd of 2.81 μM
- Solid appearance
- White to off-white color
- Purity of 99.77%
- For research use only
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Matrix Scientific QUINOLINE-8-CARBOXYLIC ACID-1G
Quinoline-8-carboxylic acid, 98%; 1g,C10H7NO2, MFCD00047619, mw 173.17, [86-59-9]
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Apexbio Technology LLC CYC116 693228-63-6 200mg
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CYC116 (CAS 693228-63-6) is a small-molecule inhibitor targeting Aurora kinases A and B critical serine/threonine kinases involved in mitotic processes such as centrosome maturation spindle assembly and cytokinesis CYC116 demonstrates potent inhibition with IC50 values of 44 nM for Aurora A and 19 nM for Aurora B and Ki values of 8 nM and 9 2 nM respectively In vitro studies indicate that CYC116 disrupts mitosis induces polyploidy and triggers cell death in cancer cells Preliminary in vivo assessments reveal oral bioavailability and antitumor activity CYC116 is currently under evaluation in phase I clinical trials as an anticancer agent
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